"Lithium" is a song by the American rock band Evanescence. It was released in 2006 on their second studio album, "The Open Door." The song is written in the key of E major and was composed by Amy Lee, the lead vocalist of the band. The lyrics of "Lithium" convey themes of emotional struggle and the desire for escape. Interestingly, the song was inspired by Amy Lee's experiences with depression, and "Lithium" is a reference to the medication used to treat bipolar disorder. The melody of the song is haunting and powerful, with Lee's signature vocal range showcased throughout. "Lithium" remains one of Evanescence's most popular and iconic songs, shining a light on mental health topics through its evocative lyrics and captivating music.